Pemphigus Foliaceus - start here.

[Penel CIMDA moderator]

Pemphigus  Foliaceus

Pemphigus is a group of autoimmune skin diseases.  Pemphigus foliaceus is the most common in this group, and some breeds are documented to have a 'breed predisposition'. Autoantibodies are directed against the epidermis, the outer layers of the skin. You may notice pustules or crusting on the muzzle, face, lips and ears before the disease slowly progresses to the dog's trunk. The footpads may become thickened and sometimes the surface layer of the pad will lift off. Diagnosis is obtained by several skin biopsies and immunoflourescent staining. Many skin conditions take on a similar appearance so it is very important for other conditions such as demodicosis, drug eruptions etc., to be excluded before treating with immunosuppressive drugs. Secondary infection may be present and this should be treated with antibiotics.