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Author Topic: SRMA diagnosis with very high WBC  (Read 49 times)

tjh46633

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SRMA diagnosis with very high WBC
« on: July 23, 2020, 03:17:18 PM »

My 8 month old Wirehaired Pointing Griffon was just diagnosed with SRMA 2 weeks ago. We are treating with Prednisone and are seeing great results. I have no doubts that he has SRMA but I am trying to research the correlation of the following factors present at time of diagnosis:
In his CSF sample he had very high WBC. At time of diagnosis he was fighting yeast infection in both ears.

I am very curious to hear from other owners whose dog has SRMA. I am interested in finding out if you also saw elevated WBC in the CSF and if your canine had any infections at time of diagnosis.
Thank you!
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Catherine

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Re: SRMA diagnosis with very high WBC
« Reply #1 on: July 23, 2020, 03:38:29 PM »

Have you seen this? : http://cimda.co.uk/smf/index.php?topic=25.0 It mentions elevated WBC.

Also if you put SRMA in the search function you will see several posts from owners with dogs with SRMA.
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Jo CIMDA

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Re: SRMA diagnosis with very high WBC
« Reply #2 on: July 24, 2020, 11:04:40 AM »

Hi and welcome.

I am sorry that your young boy has SRMA.  The good news is, SRMA responds very well to immunosuppressive treatment, as you have witnessed.  I do hope the immunosuppressive protocol that he is on is a good one because this is crucial if it is to bring SRMA into remission.

Elevated WBC's are seen not only with infections but with an inflammatory autoimmune disease, so this is quite usual.    Also, I have known dogs with an inflammatory AI disease to have yeast ear infections too.  So it is very likely to be connected.

http://www.theveterinaryexpert.com/ear/ear-disease-in-dogs/
Autoimmune diseases (where the immune system attacks the cells of the body)
These diseases are all very rare, and usually cause skin disease at other body locations too. However, they can result in inflammation in the ear canals and result in ear disease.


Jo

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tjh46633

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Re: SRMA diagnosis with very high WBC
« Reply #3 on: July 28, 2020, 07:59:33 PM »

Jo - Thank you very much for your response. I am glad you included the information about the ear infection. I had not thought of it as a connection, only as a "trigger".

I have seen some posts here about the prednisone/ other steroid protocols. The prednisone regiment he is on follows very closely to what is illustrated here: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1939-1676.2009.0337.x
It is scary to think about the terrible side effects of prednisone but it is good to know that the higher dosage does not improve clinical outcome and therefore is not necessary. The study conducted by NC State has some great information as well. I didn't know that Wirehaired Pointing Griffons had a predisposition to this disease before reading the results: https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15543.


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