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Hi Alistair

Your poor girl has been through a lot.  The good news is the SRMA seems to be in remission, and in herself she is very well and happy. 

Years ago it was usual to prescribe Omeprazole or other gastroprotectants when on high doses of prednisolone because of the potential issues that you have described.  In recent years, giving a gastroprotectant when on high doses of preds, is no longer practiced and therefore gastric ulcers are not uncommon.  Omeprazole is given to heal the ulcers.

I am sure you have tried everything, so please forgive me if you have considered the following.

Give smaller meals and more often.
Do you know if the gastric ulcers are healed and no longer present?   
Is the vomiting that she is producing digested or undigested food?  Is it bile?
Have you recently changed her food?
Is she fed raw, wet or dried food?
Is she drinking enough, or could she be dehydrated?
Does she still need Omeprazole, or another proton pump inhibitor, to allow the ulcer to heal fully?
Does the diarrhoea indicate that there may be a bacteria present that needs an antibiotic such a metronidazole?  Metronidazole also has the ability to slow down the gut and allow more time for the water to be removed, thereby producing firmer stools.

My feeling is that her stomach, and probably her whole digestive system, has to be given more time to return to normal. It has been through a rough time.
When she is off preds, then perhaps a probiotic can be given, but this is not advised while there is some level of immunosuppression, although 5mg a day is not a high dose. Acidophilus is a very good gut bacteria. 

Is the vet intending to reduce the preds further?  If so then perhaps you could give 2.5mg a day (see the Prof. MJ Day Protocol) and then reduce to 2.5mg every other day and then leave it off altogether.  This will have a good effect on her stomach, but only if your vet is happy that she is in remission. It is always a balance between resolution of the disease, and the side effects of the drugs. Sometimes a different immunosuppressive drug has to be given to lessen the side effects of the steroids, and your vet did this with Atopica.  It is not a very well tolerated drug, so I am not surprised, but there are many other immunosuppressive drugs that are available now, should the need arise, but she now seems in a good place, so fingers crossed! .

Relapses are not uncommon, but it is hoped with SRMA that long term remission can be achieved, and there is no longer the need for steroids.  Anecdotally, SRMA is something that often occurs in a young dog and although in the first year or so relapses can occur, long term remission is expected to follow. A good immunosuppressive drug protocol is essential. 

Trigger factors are key to maintaining remission, and although it is impossible to protect from all potential triggers such as hormones and stress,  any potential known triggers should be avoided, these include regular spot on treatments, worming and vaccinations etc.  If a dog has worms or fleas then treatment has to be given, but only if necessary. I asked the head of the RVC, if a dog has an AI disease should they be vaccinated again, and he said NO! He said that the benefits and risks have to be considered, and in a dog with a genetic predisposition to AI disease the risks are too high.   So be mindful of these potential triggers.

I hope you had a positive experience at the vets today.

Best wishes

Regarding the Omeprazole, that did not agree with my dog so I changed to Zitac and she was able to keep her food down. Is she definitely vomiting or could it be regurgitating? I found feeding my dog with her bowl raised stopped the regurgitating. Also you could try feeding her smaller meals several times during the day although obviously away from any medication that must not be given around feeding times.

Hopefully Jo will be along soon to advise about the SRMA.
Hi all - I am looking for help for my 11 month old whippet. She was diagnosed with SRMA 3 moths ago. She was on the road to recovery with prednisolone. She relapsed, the pred was increased and she developed stomach ulcers. A week in hospital and discharged with Atopica, pred. And Cerenia and omeprazole. She would not tolerate Atopica and struggled with Omeprazole.

She is currently taking, pred 5mg (vet says CRP is very good less than 10) and Famotidine. She did have a feeding tube which has been remove as she is eating well. The problem that we have is that she cannot keep any food down. She vomits approx 1-2 hours after each meal regardless of what she eats - we have tried everything.

We are no out of ideas and out of money - maxed out the insurance plus another 6k !

Her current presentation is normal - energetic, Interested and friendly - eating and drinking well (probably due to pred) but she just wont keep ant food down. We have also tried several probiotics. Cerenia also works sometimes but it feels like we are just masking the problem. She also has intermittent diarrhoea.

Booked into the vets today - any ideas what I should be asking for? Or what might help?? Many thanks in advance.

That information is appreciated Amy.

Thank you.

Thank you Jo and Catherine for your comments. My Skylar did go through a lot. I have only run into one other Husky owner whose dog also had Uveo Dermatologic Syndrome. Their dog also had eye issues, and I referred them to the same Veterinarian we used. In the end that owner chose to not do the iridectomy surgery on their dog's eye but instead had the eye removed. The surgery was a bit costly ($2500 US dollars) but the Veterinarian allowed for payments so for me that was worth it. 

I hope that original post I made might help anyone else dealing with issue and give them some hope.

~ Amy
Amy, thank you for the update. Even if people do not post on the site they can still read the information. It will give anyone who has a dog with Uveo Dermatologic Syndrome hope that it can be controlled. Also the "halo" idea sounds good although perhaps cover it with some material, padding perhaps?

I have had dogs with seizures and one can never totally relax. Life can be cruel, just when you think things are going well it throws bad things your way. Sometimes lots of bad things that make it difficult to cope but we have to think of the good times we had with our dogs and humans.

I hope you will soon have happier times.
Hi Amy, and thank you for taking the time to post an update on Skylar, and even though many years have passed, I know how difficult this must be to relive the sadness.  It never leaves us, we just have to learn how to manage it over time. They are our family for sure.  You have been through such a tough time with your family too. I do hope that that dark cloud has lifted for you, and for so many others who seem to have gone through unprecedented hard times. 

I appreciate the information you have given about Skylar's condition because even if it helps just one person who has a dog with similar symptoms, your posting has done a good job.  Anyone who has experienced looking after a dog with seizures knows how traumatic and unpredictable it is, let alone the other problems that you and Skylar had to manage.  She was a lucky girl to have had you for her family.

Wishing you and your family all the best for 2024 and beyond.

Take care


Updating this thread. It has been a long time. Sadly my girl Skylar passed in August of 2016. She battled Uveo Dermatologic Syndrome from 2011 to 2016, along with cancer. She had a number of seizures in one day, lost her eyesight from those seizures, then we discovered cancer had gone to her brain. :(  Interestingly we had the Uveo Dermatologic Syndrome under control. She had, had an iridectomy to help control pressure in one of her eyes and that surgery was a sucess, and at the time of her seizures which occurred almost two years after the iridectomy she was finally on the lowest dosages of all her medicines and the Dr. couldn't have been more happy, same for us. The seizures took us completely by surprise. When she lost her eyesight literally over night she was still her happy self and I created a "halo" out of a wire coat hanger and attached it to her harness... this allowed her to go all over the house and outside without walking to in trees, etc. Then after 4 months of being seizure free she had 8 really bad ones almost back to back and she was so confused. Our vet suggested we help her cross. It was the worst day of my life and up until now I really could not bring myself to do any updates. At that same time the family seemed to have a monster of a black cloud hanging over them. We lost my father-in-law to cancer in 2015, then his wife in 2018 to cancer, then multiple cousins of my husband to cancer. All totaled 11 people since 2015.  Sorry for being long winded. I do hope others on this site find relief and or cures for their pets.  They are our family.   
Technical questions about the forum / CIMDA site restored :)
Last post by Catherine - September 12, 2023, 08:22:56 PM
  Thanks for restoring the site, John.  :)  It is good to see it back again as there is so much important information on it to help owners of ill dogs, .
Hi Erica

I am so sorry about your dad's passing, and your mum's struggle.  Life can be so tough at times.  I understand why you have put your life on hold but it can take its toll, both emotionally and physically. 

You are doing all that you can to avoid 'triggers' but sometimes the trigger just can't be identified, and so many dogs have an AI disease when they are young and do achieve long term remission.  I hope this is true for Elsie.

Fingers crossed Erica.

All the best